Fingolimod

Fingolimod

SCHEMBL7445

CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

S1PR1S1PR2S1PR3S1PR4S1PR5

The experimentally established mechanism targets of Fingolimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
S1PR1 known ✓ P21453 11/20 1.00
S1PR3 known ✓ Q99500 9/20 1.00
S1PR4 known ✓ O95977 7/20 1.00
S1PR5 known ✓ Q9H228 5/20 1.00
S1PR2 known ✓ O95136 5/20 0.74
TNNC1 P63316 6/20 1.00
SGPL1 O95470 1/20 1.00
GPR183 P32249 1/20 1.00
CERS2 Q96G23 1/20 1.00
SPHK2 Q9NRA0 3/20 0.78
SPHK1 Q9NYA1 1/20 0.78
ENPP2 Q13822 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3391728 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL1372656 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3394554 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3389578 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3394797 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3390328 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL18904548 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3392313 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
SCHEMBL3393539 1.00 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5
Hydrochloric Acid SCHEMBL8500527 0.98 S1PR1 (1.00) S1PR1S1PR3S1PR4TNNC1S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 19336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079927-A Hypochlorous acid activation-based methylene blue-fingolimod prodrug, and preparation method and application thereof 2026-05-26 CN claimed
CN-122094963-A Cardioprotective lipids and methods of use 2026-05-26 CN claimed
CN-122080237-A Preparation method of ovarian stem cells and application of ovarian stem cells in preparation of ovarian anti-aging drugs 2026-05-26 CN claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
WO-2026103922-A1 CHIMERIC SHUTTLING RECEPTOR 深圳市湾岛细胞科技有限公司 2026-05-21 WO claimed
WO-2026107075-A1 METHODS OF TREATING MULTIPLE SCLEROSIS WITH CD19-CD20 DUAL CAR-T CELLS GENENTECH, INC. (US) 2026-05-21 WO claimed
US-20260138973-A1 SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
US-20260138987-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CONTINEUM THERAPEUTICS INC (US) 2026-05-21 US claimed
US-20260137680-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
US-20260142011-A1 PHARMACOKINETIC MODELING SYSTEMS FOR IMPROVED THERAPEUTIC DOSING PROMETHEUS LABORATORIES INC (US) 2026-05-21 US claimed
US-6121329-A Topical administration of 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-09-19 US claimed
WO-2000041474-A2 ANTI-CD3 IMMUNOTOXINS AND THERAPEUTIC USES THEREFOR NOVARTIS AG (CH) 2000-07-20 WO claimed
WO-2000027798-A1 PRODUCTION OF 2-AMINO-2-[2-(4-C2-20-ALKYL-PHENYL)ETHYL]PROPANE-1,3-DIOLS NOVARTIS AG (CH) 2000-05-18 WO claimed
EP-0990440-A1 DRUG COMPOSITION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-04-05 EP claimed
EP-0941082-A2 NEW USE FOR 1,3-PROPANEDIOL DERIVATIVES Novartis AG (CH) 1999-09-15 EP claimed
EP-0627406-B1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL (JP) 1998-10-28 EP claimed
WO-1998022100-A2 NEW USE FOR 1,3-PROPANEDIOL DERIVATIVES NOVARTIS AG (CH) 1998-05-28 WO claimed
EP-0812588-A1 EXTERNAL PREPARATION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-12-17 EP claimed
US-5604229-A 2-amino-1,3-propanediol compound and immunosuppressant YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1997-02-18 US claimed
EP-0627406-A1 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1994-12-07 EP claimed