Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614997 | 1.00 | DRD2 (0.47) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL7614366 | 0.99 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL7614362 | 0.99 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL7619434 | 0.98 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL7619425 | 0.98 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4HTR1A | |
| SCHEMBL7857811 | 0.95 | DRD2 (0.43) | DRD2DRD3HTR1DHTR1ASLC6A4 | |
| SCHEMBL7857726 | 0.94 | DRD2 (0.44) | DRD2DRD3HTR1DHTR1ASLC6A4 | |
| SCHEMBL7859099 | 0.93 | SLC6A4 (0.49) | DRD2DRD3HTR1DHTR1ASLC6A4 | |
| SCHEMBL7859104 | 0.93 | DRD2 (0.44) | DRD2DRD3HTR1DHTR1ASLC6A4 | |
| SCHEMBL7859108 | 0.92 | SLC6A4 (0.49) | DRD2DRD3HTR1DHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822813-B1 | A COMBINATION OF A 5-HT UPTAKE INHIBITOR WITH A SELECTIVE 5-HT 1A ANTAGONIST | ASTRAZENECA AB (SE) | 2002-04-24 | — | — | EP | disclosed |
| US-5962514-A | Combination of 5-HT uptake inhibitor with a selective 5-HT1A antagonist | ASTRA AKTIEBOLAG (SE) | 1999-10-05 | — | — | US | disclosed |
| US-5616610-A | CENTRAL NERVOUS SYSTEM DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-04-01 | — | — | US | disclosed |