Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL28774544 | 1.00 | GSR (0.48) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL16038745 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL3094553 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL1675447 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL6276264 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL1675387 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL3100126 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL22157986 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Lysine SCHEMBL21796038 | 0.95 | GSR (0.53) | GSRITGB3ITGA2BDPP7DPP4 | |
| Glutamic Acid SCHEMBL16594121 | 0.94 | GSR (0.46) | GSRGRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060261-A4 | POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS | MASSACHUSETTS INST TECHNOLOGY (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1060261-A1 | POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS | Massachusetts Institute of Technology (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045132-A1 | POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-09-10 | — | — | WO | disclosed |