Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.66 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146088 | 0.94 | NLRP3 (0.73) | NLRP3 | |
| SCHEMBL7613078 | 0.92 | NLRP3 (0.56) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7617403 | 0.92 | NLRP3 (0.66) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7614879 | 0.92 | NLRP3 (0.62) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7140501 | 0.91 | NLRP3 (0.75) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7611971 | 0.89 | NLRP3 (0.61) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7611975 | 0.89 | NLRP3 (0.61) | NLRP3CA12CA1CA2CA9 | |
| SCHEMBL7622583 | 0.88 | NLRP3 (0.62) | NLRP3 | |
| SCHEMBL7137666 | 0.88 | NLRP3 (0.67) | NLRP3 | |
| SCHEMBL7613083 | 0.87 | NLRP3 (0.58) | NLRP3CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433009-B1 | TREATMENT OF AUTOIMMUNE, CARDIOVASCULAR, NERVOUS SYSTEM, GASTROINTESTINAL, RESPIRATORY SYSTEM, AND VIRAL DISORDERS; ANTIDIABETIC, ANTIARTHRITIC, ANTIINFLAMMATORY AND ANTIDEPRESSANT AGENTS | PFIZER INC | 2002-08-13 | — | — | US | disclosed |