SCHEMBL761704

SCHEMBL761704

COCOc1cccnc1C1(CNC(=O)c2ccc(Cl)cc2Cl)CCN(C(=O)O)C(C(C)(C)C)C1

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18274651 0.89 SLC6A9 (0.52) SLC6A9
SCHEMBL3495400 0.87 SLC6A9 (0.55) SLC6A9
SCHEMBL761703 0.82 SLC6A9 (0.52) SLC6A9
SCHEMBL5042121 0.78 SLC6A9 (0.57) SLC6A9
SCHEMBL760752 0.75 SLC6A9 (0.54) SLC6A9
SCHEMBL3556797 0.74 SLC6A9 (0.61) SLC6A9
SCHEMBL13032115 0.71 SLC6A9 (0.80) SLC6A9
SCHEMBL759520 0.71 SLC6A9 (0.80) SLC6A9
SCHEMBL3558262 0.70 SLC6A9 (0.56) SLC6A9
SCHEMBL2903171 0.69 SLC6A9 (0.67) SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1942733-B1 RADIOLABELED GLYCINE TRANSPORTER INHIBITORS MERCK SHARP & DOHME (US) 2012-03-21 EP disclosed