Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7613905 | 0.96 | NLRP3 (0.61) | NLRP3ALDH1A1LMNAFBP1GSTO1 | |
| SCHEMBL7137648 | 0.95 | NLRP3 (0.69) | NLRP3ALDH1A1LMNAFBP1GSTO1 | |
| SCHEMBL7144737 | 0.91 | NLRP3 (0.66) | NLRP3ALDH1A1LMNAFBP1GSTO1 | |
| SCHEMBL7142667 | 0.91 | NLRP3 (0.74) | NLRP3FBP1CA12CA1CA2 | |
| SCHEMBL7612024 | 0.87 | NLRP3 (0.69) | NLRP3FBP1CA12CA1CA2 | |
| SCHEMBL7616938 | 0.87 | NLRP3 (0.69) | NLRP3FBP1CA12CA1CA2 | |
| SCHEMBL7621810 | 0.84 | NLRP3 (0.68) | NLRP3LMNAFBP1GSTO1CA12 | |
| SCHEMBL7614656 | 0.84 | NLRP3 (0.65) | NLRP3ALDH1A1LMNAFBP1CA12 | |
| SCHEMBL7617403 | 0.83 | NLRP3 (0.66) | NLRP3ALDH1A1LMNAFBP1CA12 | |
| SCHEMBL7140501 | 0.82 | NLRP3 (0.75) | NLRP3CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |