Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609564 | 0.86 | ALDH1A1 (0.44) | KMT2ATSHRUSP2ALDH1A1HPGD | |
| SCHEMBL7614604 | 0.82 | KMT2A (0.36) | KMT2ATSHRALDH1A1HPGDCXCR5 | |
| SCHEMBL7611962 | 0.82 | KMT2A (0.41) | HSD11B1KMT2ATSHRALDH1A1 | |
| SCHEMBL6818072 | 0.81 | USP2 (0.48) | MMEHDAC9HSD11B1MMP8KMT2A | |
| SCHEMBL7614574 | 0.81 | AKR1B1 (0.40) | HSD11B1NPSR1KMT2ATSHRALDH1A1 | |
| SCHEMBL7617471 | 0.80 | AKR1B1 (0.41) | HSD11B1ALDH1A1CXCR5OXER1 | |
| SCHEMBL7611058 | 0.80 | KMT2A (0.35) | HSD11B1NPSR1KMT2ATSHRUSP2 | |
| SCHEMBL29448021 | 0.80 | KMT2A (0.44) | NPSR1KMT2ATSHRALDH1A1 | |
| SCHEMBL11529778 | 0.80 | KMT2A (0.44) | NPSR1KMT2ATSHRALDH1A1 | |
| SCHEMBL7615689 | 0.79 | AKR1B1 (0.38) | HSD11B1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180094-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2002-02-20 | — | — | EP | claimed |
| WO-2000073259-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2000-12-07 | — | — | WO | claimed |
| EP-1180094-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000073259-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2000-12-07 | — | — | WO | disclosed |