Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 6/20 | 0.58 |
| ▸ | CDK1 | P06493 | 6/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.58 |
| ▸ | RET | P07949 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | PRKCA | P17252 | 2/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | PRKACG | P22612 | 2/20 | 0.51 |
| ▸ | PRKACB | P22694 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257630 | 0.86 | CCNB2 (0.58) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL6261474 | 0.83 | HTR1A (0.65) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL3048118 | 0.83 | JAK2 (0.58) | FLT3AURKAJAK2CDK2CDK4 | |
| SCHEMBL31588329 | 0.81 | CCNB2 (0.76) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL144954 | 0.81 | CCNB2 (0.76) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL2539205 | 0.79 | CCNB2 (0.69) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL6260797 | 0.78 | CCNB2 (0.63) | CCNB2CDK1CCNB1CCNB3RET | |
| SCHEMBL30369303 | 0.77 | CDK5 (0.71) | CCNB2CDK1CCNB1CCNB3PRKCA | |
| SCHEMBL28982781 | 0.77 | CDK5 (0.71) | CCNB2CDK1CCNB1CCNB3PRKCA | |
| SCHEMBL4510383 | 0.77 | FLT3 (0.64) | CCNB2CDK1CCNB1CCNB3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002102783-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-27 | — | — | WO | disclosed |