Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2131203 | 0.98 | MAPT (0.66) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| Bromide SCHEMBL9650134 | 0.93 | HDAC1 (0.67) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| Heptane SCHEMBL11228269 | 0.90 | MAPT (0.59) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| Bromide SCHEMBL9875660 | 0.84 | MAPT (0.60) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| 5-Phenylvaleric Acid SCHEMBL503601 | 0.83 | MAPT (0.96) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL7065645 | 0.83 | MAPT (0.79) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| Bromide SCHEMBL993390 | 0.83 | MAPT (0.63) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL2553009 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL2555645 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL1008757 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228031-A2 | OMEGA CHAIN MODIFIED 15-HYDROXYEICOSATETRAENOIC ACID DERIVATIVES AND METHODS OF THEIR USE FOR THE TREATMENT OF DRY EYE | Alcon Universal, Ltd. (CH) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001034546-A2 | OMEGA CHAIN MODIFIED 15-HYDROXYEICOSATETRAENOIC ACID DERIVATIVES AND METHODS OF THEIR USE FOR THE TREATMENT OF DRY EYE | ALCON UNIVERSAL LTD. (CH) | 2001-05-17 | — | — | WO | disclosed |