Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124980 | 0.88 | PDE5A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5128625 | 0.87 | PDE5A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5118528 | 0.86 | PDE5A (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5122163 | 0.85 | PDE5A (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5113705 | 0.85 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5124591 | 0.84 | PDE5A (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5123053 | 0.83 | MEN1 (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7619727 | 0.83 | PDE5A (0.64) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7613298 | 0.83 | PDE5A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5122830 | 0.82 | KCNN3 (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6133271-A | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 2000-10-17 | — | — | US | disclosed |