Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24926176 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2HDAC4HDAC8CA1CA2 | |
| SCHEMBL19612192 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2HDAC4HDAC8CA1CA2 | |
| SCHEMBL10661795 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2HDAC4HDAC8CA1CA2 | |
| SCHEMBL11749913 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2HDAC4HDAC8CA1CA2 | |
| SCHEMBL2479629 | 0.73 | CA12 (0.34) | HDAC4HDAC8CA1CA2CA12 | |
| SCHEMBL28000332 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2CA1CA2CA12CA7 | |
| SCHEMBL6231680 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2CA1CA2CA12CA7 | |
| SCHEMBL9676689 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2CA1CA2CA12CA7 | |
| SCHEMBL25434306 | 0.70 | CA1 (0.61) | SMN1; SMN2CA1CA2CA12CA7 | |
| SCHEMBL151213 | 0.70 | CA1 (0.61) | SMN1; SMN2CA1CA2CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858445-B1 | NEW [(3-ALKOXY-PHENOXY)-ETHYL]-DIALKYLAMINE DERIVATIVES AND THEIR USE AS LOCAL ANAESTHETICS | ASTRAZENECA AB (SE) | 2002-03-27 | — | — | EP | disclosed |
| US-6310252-B1 | AS TOPICAL ANAESTHETICS | ASTRAZENECA AB (SE) | 2001-10-30 | — | — | US | disclosed |