Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 12/20 | 0.60 |
| ▸ | ITGB2 | P05107 | 9/20 | 0.60 |
| ▸ | ICAM1 | P05362 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7613911 | 0.92 | ITGAL (0.62) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL7624289 | 0.89 | ITGAL (0.75) | ITGALITGB2ICAM1 | |
| SCHEMBL7612983 | 0.88 | ITGAL (0.62) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL27492007 | 0.88 | ITGAL (0.78) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6201065 | 0.88 | ITGAL (0.78) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL7620000 | 0.87 | ITGAL (0.47) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL7624300 | 0.85 | ITGAL (0.74) | ITGALITGB2ICAM1 | |
| SCHEMBL7611696 | 0.84 | ITGAL (0.62) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL27492008 | 0.83 | ITGB2 (0.40) | ITGALITGB2ICAM1SMN1; SMN2KDM4E | |
| SCHEMBL6198130 | 0.83 | ITGAL (0.74) | ITGALITGB2ICAM1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | claimed |
| EP-1140814-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000059880-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-10-12 | — | — | WO | claimed |
| WO-2000039081-A2 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-07-06 | — | — | WO | claimed |