Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600359 | 0.80 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL6297543 | 0.76 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6295934 | 0.74 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6093773 | 0.71 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL6093661 | 0.69 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5600335 | 0.69 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL7624509 | 0.67 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5611393 | 0.67 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL6094839 | 0.67 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6093592 | 0.65 | CRHR1 (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448261-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC AND NEUROLOGICAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-10 | — | — | US | disclosed |
| US-6107300-A | CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0968210-A1 | METHOD OF MAKING ARYLAMINO TRIAZOLOPYRIDINES | Du Pont Pharmaceuticals Company (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998042706-A1 | METHOD OF MAKING ARYLAMINO TRIAZOLOPYRIDINES | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-10-01 | — | — | WO | disclosed |