Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 14/20 | 0.54 |
| ▸ | ACHE | P22303 | 13/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606798 | 0.95 | BCHE (0.54) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7606546 | 0.87 | BCHE (0.46) | BCHEACHEMAPTTP53TRPV1 | |
| SCHEMBL7619454 | 0.87 | SLC2A1 (0.59) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7619463 | 0.87 | SLC2A1 (0.59) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7614846 | 0.85 | BCHE (0.56) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7612355 | 0.85 | BCHE (0.46) | BCHEACHESLC2A1MAPTMEN1 | |
| SCHEMBL7620255 | 0.85 | BCHE (0.58) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7612949 | 0.84 | BCHE (0.58) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7606787 | 0.84 | SLC2A1 (0.65) | BCHEACHESLC2A1MAPTTP53 | |
| SCHEMBL7606790 | 0.84 | SLC2A1 (0.65) | BCHEACHESLC2A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |