Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 12/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.46 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846458 | 0.90 | PTPN1 (0.59) | PTPN1PTPN2PGK1PGK2PTPN5 | |
| SCHEMBL7626428 | 0.83 | PTPN1 (0.44) | PTPN1PTPN2 | |
| SCHEMBL5398102 | 0.77 | PGK1 (0.44) | PTPN1PTPN2PGK1PGK2PTPN5 | |
| SCHEMBL7620396 | 0.77 | S1PR1 (0.35) | PTPN1PTPN2PTPN5 | |
| SCHEMBL7625404 | 0.76 | PTPN1 (0.45) | PTPN1PTPN2 | |
| SCHEMBL7618272 | 0.75 | PTPN1 (0.41) | PTPN1PTPN2 | |
| SCHEMBL7168580 | 0.75 | PTPN1 (0.78) | PTPN1PTPN2 | |
| SCHEMBL7625008 | 0.68 | PTPN1 (0.54) | PTPN1PTPN2 | |
| SCHEMBL7165173 | 0.67 | PTPN1 (0.62) | PTPN1PTPN2PTPN5 | |
| SCHEMBL7623932 | 0.67 | PTPN1 (0.56) | PTPN1PTPN2PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486142-B2 | A,A-DIFLUOROBENZYLPHOSPHONIC ACID DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-11-26 | — | — | US | disclosed |
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | MERCK FROSST CANADA LTD. (CA) | 2002-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | PPM1B, PTPRO, PTPA | PTPN1 13/4885PTPN2 32/4885PGK1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.