Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378790 | 0.80 | CRBN (0.46) | CRBNKMT2AALDH1A1ACHECYP19A1 | |
| SCHEMBL7616399 | 0.80 | CRBN (0.46) | CRBNKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10378789 | 0.80 | CRBN (0.46) | CRBNKMT2AALDH1A1ACHECYP19A1 | |
| SCHEMBL7627822 | 0.80 | CRBN (0.46) | CRBNKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10671026 | 0.78 | NOTUM (0.40) | CRBNNOTUM | |
| SCHEMBL10692994 | 0.78 | SRD5A1 (0.41) | CRBNACHEMETAP1RAB9A | |
| SCHEMBL10674343 | 0.78 | SRD5A1 (0.40) | CRBNALDH1A1ACHERAB9ADDB1 | |
| SCHEMBL10687019 | 0.78 | CRBN (0.40) | CRBNHDAC1HDAC6METAP1DDB1 | |
| SCHEMBL10377619 | 0.78 | NOTUM (0.43) | CRBNNOTUMMETAP1 | |
| SCHEMBL10377620 | 0.75 | CRBN (0.40) | CRBNALDH1A1KDM4EMAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1098650-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004905-A1 | BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2000-02-03 | — | — | WO | disclosed |
| EP-0197318-B1 | Benzo[C]-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4742171-A | AROMATIZATION, REARRANGEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4670562-A | MEMORY ENHANCEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4652567-A | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-03-24 | — | — | US | disclosed |