Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15923398 | 1.00 | DRD2 (0.55) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL2802924 | 1.00 | DRD2 (0.55) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL20530530 | 1.00 | DRD2 (0.55) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL1772642 | 1.00 | DRD2 (0.55) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL7432568 | 0.98 | DRD2 (0.57) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL6626845 | 0.91 | DRD2 (0.59) | DRD2DRD4DRD3L3MBTL1KCNH2 | |
| SCHEMBL16418450 | 0.91 | GAA (0.51) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL3977735 | 0.89 | DRD2 (0.46) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL3977737 | 0.89 | DRD2 (0.46) | DRD2DRD4DRD3GAAL3MBTL1 | |
| SCHEMBL14095592 | 0.89 | PRMT1 (0.54) | DRD3GAAL3MBTL1KCNH2PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105558-C | 2,2-dichloroalkane carboxylic acids, process for preparing the same, medicament containing the same and use for treating insulin resistance | ROCHE DIAGNOSTICS GMBH (DE) | 2003-04-16 | — | — | CN | disclosed |
| EP-0790824-B1 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-06 | — | — | EP | disclosed |
| US-5968982-A | TREATMENT OF DIABETES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-10-19 | — | — | US | disclosed |
| CN-1171050-A | 2, 2-Dichloroalkanecarboxylic acids, method for the production thereof, medicaments containing the same and use thereof for the treatment of insulin resistance | BOEHRINGER MANNHEIM GMBH (DE) | 1998-01-21 | — | — | CN | disclosed |
| EP-0103252-A2 | Aryloxyalkyl amines, process for their preparation and their use in combating unwanted plant growth | BASF Aktiengesellschaft (DE) | 1984-03-21 | — | — | EP | disclosed |