Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482514 | 0.89 | MEN1 (0.56) | CRHR1MEN1KMT2A | |
| SCHEMBL8204710 | 0.82 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL7619647 | 0.79 | CRHR1 (0.56) | CRHR1MEN1KMT2A | |
| SCHEMBL7621575 | 0.79 | CRHR1 (0.60) | CRHR1MEN1KMT2A | |
| SCHEMBL7621579 | 0.79 | CRHR1 (0.60) | CRHR1MEN1KMT2A | |
| SCHEMBL7539837 | 0.78 | CRHR1 (0.55) | CRHR1MEN1KMT2A | |
| SCHEMBL7619664 | 0.77 | CRHR1 (0.59) | CRHR1 | |
| Dimethylamine SCHEMBL7476721 | 0.76 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL7483647 | 0.76 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL7619210 | 0.76 | CRHR1 (0.58) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448261-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC AND NEUROLOGICAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-10 | — | — | US | disclosed |
| US-6107300-A | CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS (US) | 2000-08-22 | — | — | US | disclosed |