Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Teclothiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.83 |
| ▸ | CA1 | P00915 | 3/20 | 0.83 |
| ▸ | CA2 | P00918 | 3/20 | 0.83 |
| ▸ | CA7 | P43166 | 2/20 | 0.83 |
| ▸ | HTT | P42858 | 1/20 | 0.83 |
| ▸ | CA12 | O43570 | 1/20 | 0.83 |
| ▸ | CA4 | P22748 | 1/20 | 0.83 |
| ▸ | CA6 | P23280 | 1/20 | 0.83 |
| ▸ | CA5A | P35218 | 1/20 | 0.83 |
| ▸ | CA9 | Q16790 | 1/20 | 0.83 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.83 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichlormethiazide SCHEMBL25493 | 0.91 | LMNA (1.00) | LMNACA1CA2CA7HTT | |
| Trichlormethiazide SCHEMBL25492 | 0.91 | LMNA (1.00) | LMNACA1CA2CA7HTT | |
| Trichlormethiazide SCHEMBL29356280 | 0.91 | LMNA (1.00) | LMNACA1CA2CA7HTT | |
| Teclothiazide SCHEMBL309921 | 0.91 | LMNA (0.65) | LMNACA1CA2CA7HTT | |
| Teclothiazide SCHEMBL5324541 | 0.86 | LMNA (0.61) | LMNACA1CA2CA7HTT | |
| SCHEMBL29132639 | 0.80 | LMNA (0.79) | LMNACA1CA2CA7HTT | |
| SCHEMBL30561865 | 0.80 | LMNA (0.79) | LMNACA1CA2CA7HTT | |
| Trichlormethiazide SCHEMBL20775173 | 0.80 | LMNA (0.78) | LMNACA1CA2CA7HTT | |
| Methyclothiazide SCHEMBL10380303 | 0.79 | CHRM1 (0.77) | LMNACA1CA2CA7HTT | |
| Cyclopenthiazide SCHEMBL13723122 | 0.78 | LMNA (0.85) | LMNACA1CA2CA7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235561-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | Panacea Biotec Limited (IN) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001039749-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | PANACEA BIOTEC LIMITED (IN) | 2001-06-07 | — | — | WO | disclosed |