Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.53 |
| ▸ | HMGCR | P04035 | 5/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28658232 | 1.00 | PTPN7 (0.53) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL1198893 | 0.98 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL1259953 | 0.91 | — | — | |
| SCHEMBL4865379 | 0.86 | HMGCR (0.59) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL8761928 | 0.86 | HMGCR (0.59) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL10464578 | 0.84 | HMGCR (0.58) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL1258131 | 0.81 | — | — | |
| SCHEMBL23116350 | 0.80 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL23116295 | 0.80 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1ALDH1A1 | |
| SCHEMBL23116298 | 0.80 | PTPN7 (0.61) | PTPN7HMGCRRECQLTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444832-B1 | OSTEOPOROSIS | ESSWEIN ANGELIKA (DE) | 2002-09-03 | — | — | US | disclosed |
| US-4456619-A | Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial walls | SANDOZ, INC. (US) | 1984-06-26 | — | — | US | disclosed |