Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 5/20 | 0.61 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142783 | 1.00 | SRD5A2 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL9129526 | 0.85 | SRD5A2 (0.59) | SRD5A2SRD5A1AR | |
| SCHEMBL9542235 | 0.83 | SRD5A1 (0.41) | SRD5A2SRD5A1AR | |
| SCHEMBL9542228 | 0.83 | SRD5A1 (0.41) | SRD5A2SRD5A1AR | |
| SCHEMBL7622722 | 0.81 | SRD5A2 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL8543608 | 0.76 | SRD5A2 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL8543612 | 0.76 | SRD5A2 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL5907001 | 0.76 | SRD5A2 (0.73) | SRD5A2SRD5A1AR | |
| SCHEMBL14477862 | 0.76 | SRD5A2 (0.73) | SRD5A2SRD5A1AR | |
| SCHEMBL13844000 | 0.76 | SRD5A2 (0.73) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432971-B2 | Method of prevention of prostatic carcinoma with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| US-6268376-B1 | Method of prevention of prostatic carcinoma with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |
| US-6046183-A | SYNERGISTIC MIXTURE OF FINASTERIDE AND DOXAZOSIN | MERCK & CO., INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5629318-A | Method of treatment of chronic prostatitis with 17β-N-monosubstituted-carbamoyl-4-aza-5α-androst-1-en-3-ones | MERCK & CO., INC. (US) | 1997-05-13 | — | — | US | disclosed |
| US-5571817-A | WHICH ARE TESTOSTERONE-REDUCTASE INHIBITORS;TOPICAL APPLICATION | MERCK & CO., INC. (US) | 1996-11-05 | — | — | US | disclosed |