Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 19/20 | 0.67 |
| ▸ | ACVR1 | Q04771 | 19/20 | 0.67 |
| ▸ | BMPR1A | P36894 | 16/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 13/20 | 0.67 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769221 | 0.85 | ACVRL1 (0.73) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL744757 | 0.85 | ACVRL1 (0.69) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL768836 | 0.84 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL769195 | 0.84 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL769234 | 0.84 | ACVRL1 (0.71) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL745958 | 0.84 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL750197 | 0.84 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL768977 | 0.84 | ACVRL1 (0.67) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL768525 | 0.82 | CYP11B1 (0.80) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL753680 | 0.82 | CYP11B1 (0.73) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430011-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130794-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |