SCHEMBL7624660

SCHEMBL7624660

CCCCCCC1CCNC(=O)C1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.51
ALDH1A1 P00352 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CCR2 P41597 2/20 0.39
GNAO1 P09471 3/20 0.36
PPARG P37231 1/20 0.36
DRD3 P35462 1/20 0.36
SLC6A3 Q01959 1/20 0.36
GNAI3 P08754 2/20 0.36
GNAI1 P63096 2/20 0.36
HLCS P50747 1/20 0.36
EPHX1 P07099 1/20 0.35
S1PR2 O95136 1/20 0.34
S1PR4 O95977 1/20 0.34
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
S1PR5 Q9H228 1/20 0.34
FAAH O00519 1/20 0.34
NAAA Q02083 1/20 0.34
ITGB3 P05106 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7626924 1.00 CYP1A2 (0.51) CYP1A2ALDH1A1L3MBTL1CCR2GNAO1
SCHEMBL1567651 0.98 CYP1A2 (0.53) CYP1A2ALDH1A1L3MBTL1CCR2GNAO1
SCHEMBL26718370 0.93 CYP1A2 (0.46) CYP1A2ALDH1A1L3MBTL1CCR2GNAO1
SCHEMBL9766490 0.90 CYP1A2 (0.49) CYP1A2ALDH1A1L3MBTL1CCR2PPARG
SCHEMBL5502631 0.85 CYP1A2 (0.37) CYP1A2ALDH1A1L3MBTL1
SCHEMBL11727840 0.85 CYP1A2 (0.42) CYP1A2ALDH1A1L3MBTL1CCR2GNAO1
SCHEMBL2482486 0.83 CYP1A2 (0.47) CYP1A2ALDH1A1L3MBTL1CCR2NAAA
SCHEMBL7625438 0.83 CYP1A2 (0.44) CYP1A2ALDH1A1L3MBTL1CCR2GNAO1
SCHEMBL29632519 0.82 CYP1A2 (0.46) CYP1A2ALDH1A1L3MBTL1CCR2PPARG
SCHEMBL28437706 0.82 CYP1A2 (0.46) CYP1A2ALDH1A1L3MBTL1CCR2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448286-B1 PREFERENTIALLY INHIBITS OR MODULATES INDUCIBLE OVER CONSTITUTIVE ISOFORM OF NITRIC OXIDE SYNTHASE; SIDE EFFECT REDUCTION G.D. SEARLE & CO. 2002-09-10 US disclosed
US-6071906-A INHIBITS OR MODULATES THE INDUCIBLE ISOFORM OF NITRIC OXIDE SYNTHASE OVER THE THE CONSTITUTIVE ISOFORMS; ANTIARTHRITIC, -DIABETIC, ISCHEMIC, THROMBOSIS AGENTS; CARDIOVASCULAR DISORDERS; TOXIC SHOCK SYNDROME; AUTOIMMUNE DISEASES G. D. SEARLE & CO. (US) 2000-06-06 US disclosed
US-6046211-A TREATMENT OF ARTHRITIS OR INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA (ALLODYNIA), CEREBRAL ISCHEMIA AND OTHER CNS DISORDERS G.D. SEARLE & CO. (US) 2000-04-04 US disclosed
EP-0724570-B1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS SEARLE & CO (US) 1999-03-03 EP disclosed
EP-0897912-A1 Amidino derivatives useful as nitric oxide synthase inhibitors G.D. SEARLE & CO. (US) 1999-02-24 EP disclosed
US-5854234-A Amidino dervatives useful as nitric oxide synthase inhibitors G. D. SEARLE & CO. (US) 1998-12-29 US disclosed
EP-0724570-A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1996-08-07 EP disclosed
WO-1995011231-A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G. D. SEARLE & CO. (US) 1995-04-27 WO disclosed