Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5537944 | 0.84 | NPC1 (0.40) | KDM4EALDH1A1POLBTSHRHPGD | |
| Hydrochloric Acid SCHEMBL7252504 | 0.83 | NPC1 (0.39) | KDM4EALDH1A1POLBTSHRHPGD | |
| SCHEMBL2924995 | 0.82 | NPC1 (0.40) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5476492 | 0.80 | MAPT (0.36) | KDM4EALDH1A1POLBTSHRHPGD | |
| Hydrochloric Acid SCHEMBL5474632 | 0.80 | NPC1 (0.44) | LMNANPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL7251372 | 0.79 | MEN1 (0.36) | KDM4EALDH1A1POLBTSHRHPGD | |
| SCHEMBL2930590 | 0.79 | MAPT (0.37) | KDM4EALDH1A1POLBTSHRHPGD | |
| Hydrochloric Acid SCHEMBL7251861 | 0.78 | SMN1; SMN2 (0.43) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7618817 | 0.78 | SMN1; SMN2 (0.43) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2926247 | 0.78 | SMN1; SMN2 (0.45) | LMNANPC1RAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | disclosed |