Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | LTA4H | P09960 | 11/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7629708 | 0.97 | LMNA (0.66) | LMNAL3MBTL1LTA4HS1PR4S1PR1 | |
| SCHEMBL7627502 | 0.96 | LMNA (0.64) | LMNAL3MBTL1LTA4HS1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL7918644 | 0.95 | LMNA (0.63) | LMNAL3MBTL1LTA4HS1PR4S1PR1 | |
| SCHEMBL6497674 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL3488457 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL17320238 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL8558255 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL2185137 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL8378949 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 | |
| SCHEMBL2183912 | 0.88 | LMNA (0.79) | LMNAL3MBTL1S1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350892-B1 | ENZYME INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-26 | — | — | US | disclosed |
| EP-1140791-A4 | SELECTIVE CPLA 2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140791-A2 | SELECTIVE CPLA 2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6255496-B1 | CYTOSOLIC PHOSPHATIDE 2-ACYLHYDROLASE ENZYME INHIBITORS; CONTROLLING INFLAMMATORY DISEASES | BRISTOL-MYERS SQUIBB COMPANY | 2001-07-03 | — | — | US | disclosed |
| WO-1999015129-A2 | SELECTIVE cPLA2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |