SCHEMBL7626470

SCHEMBL7626470

C=C(c1ccc(C)cc1)c1cc(Br)ccc1OC(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.41
ALDH1A1 P00352 7/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
POLB P06746 3/20 0.39
STAT3 P40763 1/20 0.38
AR P10275 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.37
LMNA P02545 2/20 0.37
ALOX12 P18054 1/20 0.37
HTT P42858 1/20 0.37
MEN1 O00255 1/20 0.36
IDO1 P14902 1/20 0.35
TDO2 P48775 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7635746 0.85 KCNK3 (0.46) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7628654 0.80 MAPT (0.51) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7628158 0.80 IDO1 (0.33) ALDH1A1IDO1TDO2KCNK3KCNK9
SCHEMBL8030250 0.79 CYP2C9 (0.43) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7634532 0.77 KMT2A (0.40) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL7632175 0.76 IDO1 (0.31) IDO1TDO2
SCHEMBL7626381 0.75 MAOA (0.50) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL16960398 0.75 PTGDR2 (0.45) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL16960906 0.72 AR (0.42) MAPTALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL31606917 0.71 AR (0.47) MAPTALDH1A1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975573-B1 TRISUBSTITUTED PHENYL DERIVATIVES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY ALLERGAN SALES INC (US) 2002-09-18 EP disclosed
US-6235923-B1 RETINOIDS AND CELL DIFFERENTIATION ALLERGAN SALES, INC. 2001-05-22 US disclosed
US-6225494-B1 TREATING SKIN DISORDERS, REDUCED SIDE EFFECTS ALLERGAN SALES, INC. 2001-05-01 US disclosed
US-6037488-A COMPOUNDS SUCH AS 4-((4'-ISOPROPOXY-3'-(1-M-TOLYL)VINYL)PHENYLETHYNYL)BENZOIC ACID ALLERGAN SALES, INC. (US) 2000-03-14 US disclosed
EP-0975573-A1 TRISUBSTITUTED PHENYL DERIVATIVES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY Allergan Sales, Inc. (US) 2000-02-02 EP disclosed
WO-1998047854-A1 TRISUBSTITUTED PHENYL DERIVATIVES HAVING RETINOID AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY ALLERGAN SALES, INC. (US) 1998-10-29 WO disclosed