Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | GLA | P06280 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | STAT6 | P42226 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | GMNN | O75496 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449959 | 0.90 | TOP1 (0.79) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL7630113 | 0.89 | TOP1 (0.70) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL10130708 | 0.89 | TOP1 (0.76) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL7974625 | 0.89 | TOP1 (0.77) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL2031817 | 0.89 | TOP1 (0.76) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL7976717 | 0.88 | TOP1 (0.75) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL7976814 | 0.88 | TOP1 (0.75) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL27480521 | 0.88 | TOP1 (0.77) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL5320938 | 0.88 | TOP1 (0.77) | TOP1ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL10983845 | 0.87 | TOP1 (0.73) | TOP1ALDH1A1GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885230-B1 | CAMPTOTHECIN DERIVATIVES AND THE USE THEREOF AS ANTITUMOR AGENTS | IST NAZ STUD CURA DEI TUMORI (IT) | 2002-07-24 | — | — | EP | disclosed |
| US-6306868-B1 | ISOMERS OF FOR ANTITUMOR AGENTS | ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2001-10-23 | — | — | US | disclosed |
| US-6130227-A | 7-Substituted camptothecin derivatives and methods for inhibiting the growth of tumor cells therewith | ISTITUTO NAZIONAL PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2000-10-10 | — | — | US | disclosed |