Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | STAT6 | P42226 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130708 | 1.00 | TOP1 (0.76) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL10983845 | 0.94 | TOP1 (0.73) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL11197250 | 0.93 | TOP1 (0.72) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL4449959 | 0.92 | TOP1 (0.79) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL10976685 | 0.91 | TOP1 (0.73) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL7974625 | 0.90 | TOP1 (0.77) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL7976717 | 0.89 | TOP1 (0.75) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL7976814 | 0.89 | TOP1 (0.75) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL7626555 | 0.89 | TOP1 (0.73) | TOP1ALDH1A1GLAMEN1RECQL | |
| SCHEMBL28220285 | 0.89 | TOP1 (0.73) | TOP1ALDH1A1GLAMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170900-B1 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM | SIGMA TAU IND FARMACEUTI (IT) | 2012-12-12 | — | — | EP | claimed |
| US-8269007-B2 | Crystalline form II of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA (IT) | 2012-09-18 | — | — | US | claimed |
| JP-4693410-B2 | — | — | 2011-06-01 | — | — | JP | claimed |
| US-20100249414-A1 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-09-30 | — | — | US | claimed |
| EP-2170900-A1 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2010-04-07 | — | — | EP | claimed |
| EP-1511752-B3 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2010-03-10 | — | — | EP | claimed |
| WO-2009016068-A1 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-02-05 | — | — | WO | claimed |
| EP-1719775-B1 | Camptothecins with a modified lactone ring | SIGMA TAU IND FARMACEUTI (IT) | 2008-08-06 | — | — | EP | claimed |
| US-7273873-B2 | Camptothecins with a modified lactone ring | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-09-25 | — | — | US | claimed |
| EP-1511752-B8 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2007-04-18 | — | — | EP | claimed |
| EP-1719775-A1 | Camptothecins with a modified lactone ring | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-11-08 | — | — | EP | claimed |
| EP-1511752-B1 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA TAU IND FARMACEUTI (IT) | 2006-09-13 | — | — | EP | claimed |
| US-20050154003-A1 | Camptothecins with a modified lactone ring | ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI (IT) | 2005-07-14 | — | — | US | claimed |
| EP-1511752-A2 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2005-03-09 | — | — | EP | claimed |
| WO-2003101995-A2 | CAMPTOTHECINS WITH A MODIFIED LACTONE RING | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-12-11 | — | — | WO | claimed |
| JP-57116076-A | — | — | None | — | — | JP | disclosed |
| EP-2443125-B1 | CAMPTOTHECIN DERIVATIVES | THRESHOLD PHARMACEUTICALS INC (US) | 2014-11-26 | — | — | EP | disclosed |
| US-4399276-A | 7-Substituted camptothecin derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1983-08-16 | — | — | US | disclosed |
| EP-0056692-A1 | 7-Substituted camptothecin derivatives and process for their preparation | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1982-07-28 | — | — | EP | disclosed |
| JP-S57116076-A | NOVEL CAMPTOTHECIN DERIVATIVE AND ITS PREPARATION | YAKULT HONSHA CO LTD | 1982-07-19 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249414-A1 | CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM | TOP2B, TOP2A, TOP1 | TOP1 3/4885ALDH1A1 2545/4885GLA 3272/4885 |
| US-20050154003-A1 | Camptothecins with a modified lactone ring | TOP1, TOP2B, TOP2A | TOP1 1/4885ALDH1A1 1671/4885GLA 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.