Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7628054 | 0.71 | ALDH1A1 (0.35) | BRD4BRD2ALDH1A1MEN1PKM | |
| SCHEMBL7627573 | 0.69 | BRD4 (0.39) | BRD4BRD2ALDH1A1PIK3CD | |
| SCHEMBL16771540 | 0.69 | EHMT2 (0.38) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL26197005 | 0.69 | ALDH1A1 (0.36) | BRD4BRD2ALDH1A1 | |
| SCHEMBL8762738 | 0.68 | ALDH1A1 (0.37) | BRD4BRD2LMNAALDH1A1PIK3CD | |
| SCHEMBL27497138 | 0.68 | ALDH1A1 (0.37) | BRD4BRD2LMNAALDH1A1PIK3CD | |
| SCHEMBL2999035 | 0.68 | BRD4 (0.41) | BRD4BRD2LMNAALDH1A1PIK3CD | |
| SCHEMBL4583515 | 0.68 | BRD4 (0.37) | BRD4BRD2LMNAALDH1A1PIK3CD | |
| SCHEMBL5553820 | 0.68 | RCE1 (0.45) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7627567 | 0.67 | PIK3CD (0.42) | LMNAALDH1A1PIK3CDTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |