SCHEMBL7627658

SCHEMBL7627658

Clc1ccc(COc2ccc(Cn3cccn3)cc2Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.50
GAA P10253 4/20 0.50
SMN1; SMN2 Q16637 3/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
HPGD P15428 2/20 0.46
LMNA P02545 1/20 0.46
MRGPRX4 Q96LA9 3/20 0.44
BRD4 O60885 1/20 0.43
BRD2 P25440 1/20 0.43
BRD3 Q15059 1/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
KDM4E B2RXH2 1/20 0.42
KAT7 O95251 1/20 0.42
KAT6A Q92794 1/20 0.42
TACR2 P21452 1/20 0.41
HTT P42858 2/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8380240 0.82 GAA (0.50) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL3397894 0.80 GAA (0.67) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL8380832 0.78 CYP2C19 (0.46) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL18235820 0.77 GAA (0.59) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL8383297 0.76 ADRB3 (0.48) MAPTGAAMEN1KMT2AHPGD
SCHEMBL8384881 0.76 GAA (0.46) MAPTGAAMEN1KMT2ALMNA
SCHEMBL3918034 0.74 HTT (0.47) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL7630025 0.74 HDAC1 (0.45) MAPTGAASMN1; SMN2MEN1KMT2A
SCHEMBL13321693 0.74 MRGPRX4 (0.71) SMN1; SMN2KMT2AHPGDMRGPRX4NPC1
SCHEMBL8382530 0.74 MAPT (0.55) MAPTGAASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754683-B1 ETHER COMPOUND, USE THEREOF, AND INTERMEDIATE FOR PRODUCING THE COMPOUND SUMITOMO CHEMICAL CO (JP) 2002-08-14 EP disclosed
US-5684022-A ANTIFERTILITY AGENT PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-11-04 US disclosed
EP-0754683-A1 ETHER COMPOUND, USE THEREOF, AND INTERMEDIATE FOR PRODUCING THE COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-01-22 EP disclosed