Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762670 | 0.95 | HRH1 (0.45) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL739323 | 0.92 | HRH1 (0.42) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL739324 | 0.92 | HRH1 (0.42) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL762972 | 0.92 | HRH1 (0.45) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL762969 | 0.92 | HRH1 (0.46) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL763356 | 0.91 | HRH1 (0.45) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL763197 | 0.88 | HRH1 (0.47) | HRH1CYP2D6KCNH2CHRM1ALDH1A1 | |
| SCHEMBL763295 | 0.87 | TP53 (0.44) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL741578 | 0.87 | KCNH2 (0.45) | HRH1CYP2D6KCNH2CHRM1PIK3CD | |
| SCHEMBL741579 | 0.87 | KCNH2 (0.45) | HRH1CYP2D6KCNH2CHRM1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |