Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623459 | 1.00 | HDAC6 (0.34) | HDAC6HDAC1HDAC4CCNE1CDK2 | |
| SCHEMBL7620497 | 1.00 | HDAC6 (0.34) | HDAC6HDAC1HDAC4CCNE1CDK2 | |
| SCHEMBL7621784 | 0.84 | POLB (0.51) | POLBADORA2A | |
| SCHEMBL7619424 | 0.84 | POLB (0.51) | POLBADORA2A | |
| SCHEMBL3289989 | 0.71 | HPRT1 (0.39) | CCNE1CDK2CDK1CCNB1PNP | |
| Lb80317 SCHEMBL2905773 | 0.71 | POLB (0.39) | CCNE1CDK2CDK1CCNB1POLB | |
| SCHEMBL4270165 | 0.71 | CCNE1 (0.36) | HDAC6HDAC1HDAC4CCNE1CDK2 | |
| SCHEMBL3291258 | 0.70 | POLB (0.38) | HDAC6HDAC1HDAC4CCNE1CDK2 | |
| SCHEMBL3293399 | 0.70 | PNP (0.36) | HDAC6HDAC1HDAC4CCNE1CDK2 | |
| SCHEMBL3293421 | 0.70 | PNP (0.36) | HDAC6HDAC1HDAC4CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444656-B1 | (5R)-(2-AMINO-6-HYDROXY-PURIN-9-YLMETHYL)-(4R)-AZIDO-TETRAHYDR O-FURAN-(2S)- PHOSPHONATE; PARTICULARLY AGAINST HIV AND/OR HBV INFECTIONS | BIOCHEM PHARMA, INC. (CA) | 2002-09-03 | — | — | US | claimed |