SCHEMBL7630341

SCHEMBL7630341

N#Cc1cc(=O)c2cccc(C=Cc3ccc4c(c3)CC(COCc3ccc(F)cc3)O4)c2o1

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 2/20 0.41
LMNA P02545 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7630340 1.00 PRKDC (0.41) PRKDCLMNAKMT2A
SCHEMBL7634359 0.88 PRKDC (0.41) PRKDCLMNAKMT2A
SCHEMBL7634364 0.88 PRKDC (0.41) PRKDCLMNAKMT2A
SCHEMBL7626681 0.87 PRKDC (0.40) PRKDCLMNAKMT2A
SCHEMBL7626670 0.87 PRKDC (0.40) PRKDCLMNAKMT2A
SCHEMBL7636912 0.86 PRKDC (0.39) PRKDCLMNAKMT2A
SCHEMBL7634078 0.84 KMT2A (0.40) PRKDCLMNAKMT2A
SCHEMBL7634085 0.84 KMT2A (0.40) PRKDCLMNAKMT2A
SCHEMBL7633114 0.83 PRKDC (0.37) PRKDCLMNA
SCHEMBL7633117 0.83 PRKDC (0.37) PRKDCLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888327-B1 BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION MENARINI LAB (ES) 2002-06-12 EP disclosed
US-5990142-A ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS HAVING GOOD ORAL ADSORPTION AND BIOAVAILABILITY; CARDIOTONIC AND ANTIISCHEMIC AGENTS LABORATORIOS MENARINI S.A. (ES) 1999-11-23 US disclosed