Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TCF4 | P15884 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931629 | 0.88 | ALDH1A1 (0.53) | KMT2AALDH1A1LMNAHTTMAPT | |
| SCHEMBL31013995 | 0.84 | CYP2C9 (0.50) | KMT2AALDH1A1LMNAHTTMAPT | |
| SCHEMBL7632373 | 0.83 | GAA (0.53) | KMT2AALDH1A1LMNAHTTGAA | |
| SCHEMBL2231769 | 0.79 | ALDH1A1 (0.53) | KMT2AALDH1A1LMNAGAAMEN1 | |
| SCHEMBL6496116 | 0.79 | CYP1A1 (0.52) | KMT2AALDH1A1LMNAHTTMAPT | |
| SCHEMBL7632562 | 0.79 | ALDH1A1 (0.78) | KMT2AALDH1A1LMNAHTTMAPT | |
| SCHEMBL7632566 | 0.79 | ALDH1A1 (0.78) | KMT2AALDH1A1LMNAHTTMAPT | |
| Methyl Syringate SCHEMBL211747 | 0.78 | MEN1 (0.61) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| SCHEMBL7636534 | 0.78 | ALDH1A1 (0.48) | KMT2AALDH1A1LMNAHTTMAPT | |
| SCHEMBL7630261 | 0.77 | KMT2A (0.46) | KMT2AALDH1A1LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6459001-B1 | Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2002-10-01 | — | — | US | disclosed |
| US-6268520-B1 | USED FORPREPARATION OF OPTICALLY ACTIVE OR RACEMIC COLCHICINE AND THIOCOLCHICINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 2001-07-31 | — | — | US | disclosed |
| US-6221907-B1 | Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same | HOECHST MARION ROUSSEL (FR) | 2001-04-24 | — | — | US | disclosed |