Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473106 | 0.97 | TSHR (0.53) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL11324866 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| Silver SCHEMBL7634821 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL8754912 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| Methylamine SCHEMBL30526918 | 0.92 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| Trimethylammonium SCHEMBL138563 | 0.89 | TSHR (0.45) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL29455298 | 0.81 | TSHR (0.43) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL20723411 | 0.81 | TSHR (0.43) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL7627884 | 0.81 | ACHE (0.38) | TSHRACHEALDH1A1CA1CA2 | |
| Tetraphenylphosphonium SCHEMBL8817167 | 0.81 | ACHE (0.38) | TSHRACHEALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755971-B1 | Molding resin, composition containing the same, and processes for producing them | TOSOH CORP (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-5962599-A | ETHYLENE-HEXENE COPOLYMER | TOSOH CORPORATION (JP) | 1999-10-05 | — | — | US | disclosed |
| EP-0755971-A2 | Molding resin, composition containing the same, and processes for producing them | Tosoh Corporation (JP) | 1997-01-29 | — | — | EP | disclosed |