Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7639984 | 0.91 | CYP2D6 (0.47) | CYP2D6KMT2ALMNAMMEPPARG | |
| SCHEMBL7644319 | 0.80 | CYP2D6 (0.46) | CYP2D6PPARGPPARAMAPK1 | |
| SCHEMBL6237736 | 0.76 | CYP2D6 (0.57) | CYP2D6KMT2ALMNAAOC3MME | |
| SCHEMBL16816897 | 0.76 | CYP2D6 (0.57) | CYP2D6KMT2ALMNAAOC3MME | |
| SCHEMBL7925354 | 0.74 | AOC3 (0.43) | CYP2D6KMT2ALMNAAOC3MME | |
| SCHEMBL67127 | 0.73 | CYP2D6 (0.64) | CYP2D6KMT2ALMNASRCPOLB | |
| SCHEMBL28539294 | 0.73 | AOC3 (0.42) | CYP2D6KMT2ALMNAAOC3MME | |
| SCHEMBL8058593 | 0.72 | BCHE (0.44) | CYP2D6MME | |
| SCHEMBL31447452 | 0.70 | CYP2D6 (0.48) | CYP2D6POLB | |
| SCHEMBL7824857 | 0.70 | CYP2D6 (1.00) | CYP2D6KMT2ALMNASRCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |