Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418768 | 0.72 | CYP2C19 (0.47) | BCHEEPHX2CCR1METAP2METAP1 | |
| SCHEMBL1418773 | 0.72 | CYP2C19 (0.47) | BCHEEPHX2CCR1METAP2METAP1 | |
| SCHEMBL7633976 | 0.72 | CYP2D6 (0.50) | CYP2D6MME | |
| SCHEMBL7639984 | 0.70 | CYP2D6 (0.47) | CYP2D6MMEACEKDM4E | |
| SCHEMBL278375 | 0.69 | GAA (0.46) | BCHECYP2D6EPHX2CCR1METAP2 | |
| SCHEMBL1520495 | 0.69 | BCHE (0.44) | BCHEEPHX2CCR1METAP2METAP1 | |
| SCHEMBL1520497 | 0.69 | CYP1A2 (0.57) | BCHECYP2D6METAP2METAP1KDM4E | |
| SCHEMBL7644319 | 0.69 | CYP2D6 (0.46) | CYP2D6EPHX2NPC1RAB9A | |
| SCHEMBL19272538 | 0.69 | NPC1 (0.54) | BCHECYP2D6EPHX2METAP2METAP1 | |
| SCHEMBL2441628 | 0.68 | BCHE (0.45) | BCHEEPHX2CCR1METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | claimed |