Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.78 |
| ▸ | ULK1 | O75385 | 1/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736887 | 0.96 | SYK (0.85) | SYKULK1PTK2B | |
| SCHEMBL10243924 | 0.94 | SYK (0.79) | SYKPTK2B | |
| SCHEMBL17544763 | 0.91 | SYK (0.66) | SYKULK1PTK2B | |
| SCHEMBL736232 | 0.88 | SYK (1.00) | SYK | |
| SCHEMBL19654185 | 0.84 | ULK1 (0.64) | SYKULK1PTK2B | |
| SCHEMBL17547567 | 0.84 | ULK1 (0.64) | SYKULK1PTK2B | |
| SCHEMBL1071249 | 0.84 | SYK (0.56) | SYKULK1PTK2B | |
| SCHEMBL20336253 | 0.83 | KIT (0.58) | SYKULK1PTK2B | |
| SCHEMBL20336254 | 0.83 | KIT (0.58) | SYKULK1PTK2B | |
| SCHEMBL10241953 | 0.83 | SYK (0.68) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138339-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090318407-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318407-A1 | Inhibitors of protein kinases | SYK, BTK, JAK1 | SYK 1/4885ULK1 404/4885PTK2B 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.