Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 19/20 | 0.58 |
| ▸ | RARG | P13631 | 19/20 | 0.58 |
| ▸ | RARA | P10276 | 18/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238278 | 0.92 | RARA (0.69) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7638748 | 0.87 | RARA (0.46) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7633676 | 0.80 | RARA (0.83) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6235399 | 0.79 | RARA (0.53) | RARBRARGRARACYP3A4 | |
| SCHEMBL6292457 | 0.79 | RARA (0.66) | RARBRARGRARA | |
| SCHEMBL6292461 | 0.79 | RARA (0.66) | RARBRARGRARA | |
| SCHEMBL8326970 | 0.78 | RARA (0.54) | RARBRARGRARA | |
| SCHEMBL7642585 | 0.78 | RARB (0.84) | RARBRARGRARA | |
| SCHEMBL7642223 | 0.77 | RARA (0.61) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8981564 | 0.77 | RARA (0.70) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355806-B1 | REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION, AGENTS FOR TREATING SKIN-RELATED DISEASES | ALLERGEN SALES, INC. | 2002-03-12 | — | — | US | disclosed |
| US-5998471-A | SKIN DISORDERS; ANTIINFLAMMATORY AGENTS | ALLERGAN SALES, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5808083-A | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5648514-A | Substituted acetylenes having retinoid-like biological activity | ALLERGAN (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1996020930-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |