Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636070 | 1.00 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7628604 | 0.92 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7628598 | 0.92 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7283432 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5142842 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7398818 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7796450 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6305846 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6446803 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7627160 | 0.90 | KLK5 (0.44) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708085-B1 | Antiviral ethers of aspartate protease substrate isosteres | NOVARTIS AG (CH) | 2002-07-17 | — | — | EP | disclosed |
| US-5663200-A | CARBAMOYL PEPTIDE DERIVATIVES AS VIRICIDES | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0708085-A2 | Antiviral ethers of aspartate protease substrate isosteres | CIBA-GEIGY AG (CH) | 1996-04-24 | — | — | EP | disclosed |
| EP-0618222-A2 | Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid | CIBA-GEIGY AG (CH) | 1994-10-05 | — | — | EP | disclosed |