Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 18/20 | 0.50 |
| ▸ | RARB | P10826 | 18/20 | 0.50 |
| ▸ | RARG | P13631 | 18/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641992 | 0.91 | RARA (0.56) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7633717 | 0.87 | RARA (0.46) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7636209 | 0.87 | RARA (0.46) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7637339 | 0.87 | RARA (0.47) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8772615 | 0.86 | RARA (0.45) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7639392 | 0.86 | RARA (0.47) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8772612 | 0.86 | RARA (0.45) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7637426 | 0.86 | RARA (0.52) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8772586 | 0.85 | RARA (0.44) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL7636104 | 0.85 | RARA (0.63) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355806-B1 | REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION, AGENTS FOR TREATING SKIN-RELATED DISEASES | ALLERGEN SALES, INC. | 2002-03-12 | — | — | US | disclosed |
| US-5998471-A | SKIN DISORDERS; ANTIINFLAMMATORY AGENTS | ALLERGAN SALES, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5808083-A | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0800517-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5648514-A | Substituted acetylenes having retinoid-like biological activity | ALLERGAN (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1996020930-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |