Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265873 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL3265911 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL3265910 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL6866945 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL752474 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL2155095 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL3895796 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| SCHEMBL2322090 | 1.00 | PRSS1 (0.46) | PRSS1PRSS2PRSS3CES2CES1 | |
| Hydrochloric Acid SCHEMBL4260638 | 0.99 | PRSS1 (0.45) | PRSS1PRSS2PRSS3CES2CES1 | |
| Hydrochloric Acid SCHEMBL670429 | 0.99 | PRSS1 (0.45) | PRSS1PRSS2PRSS3CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013111161-A2 | PROCESS FOR THE PREPARATION OF 3-ARYL-2-METHYL-PROPANAMINE DERIVATIVES AND POLYMORPHS THEREOF | MSN LABORATORIES LIMITED (IN) | 2013-08-01 | — | — | WO | claimed |
| EP-1633697-B1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-03-11 | — | — | EP | claimed |
| US-7417170-B2 | Process for the preparation of substituted 3-aryl-butylamine compounds | GRUENENTHAL GMBH (DE) | 2008-08-26 | — | — | US | claimed |
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | GRUENENTHAL GMBH | 2006-08-31 | — | — | US | claimed |
| EP-1633697-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108658-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2004-12-16 | — | — | WO | claimed |
| EP-3210965-B2 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2026-05-13 | — | — | EP | disclosed |
| EP-3868739-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2023-10-04 | — | — | EP | disclosed |
| EP-3868739-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2023-10-04 | — | — | EP | disclosed |
| US-11739049-B2 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol | Grünenthal GmbH (DE) | 2023-08-29 | — | — | US | disclosed |
| EP-3210965-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2021-11-17 | — | — | EP | disclosed |
| EP-3210965-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2021-11-17 | — | — | EP | disclosed |
| US-20210130282-A1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | Grünenthal GmbH (DE) | 2021-05-06 | — | — | US | disclosed |
| EP-1633697-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108658-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 3-ARYL-BUTYL AMINE COMPOUNDS | Grünenthal GmbH (DE) | 2004-12-16 | — | — | WO | disclosed |
| EP-0983995-B1 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | GRUENENTHAL GMBH (DE) | 2004-03-31 | — | — | EP | disclosed |
| EP-1069106-B1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-1069106-A2 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| EP-0983995-A2 | Pharmaceutically-active dimethyl-(3-aryl-but-3-enyl)-amine compounds | Grünenthal GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0799819-A1 | Dimethyl-(3-aryl-but-3-enyl) amine derivatives with analgesic activity | Grünenthal GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739049-B2 | Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol | COMT, CYP1A1, CYP2E1 | PRSS1 894/4885PRSS2 734/4885PRSS3 1052/4885 |
| US-20060194988-A1 | Process for the preparation of substitued 3-aryl-butylamine compounds | BRD3, TYR, BBOX1 | PRSS1 2976/4885PRSS2 2842/4885PRSS3 1268/4885 |
| US-20210130282-A1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | COMT, CYP1A1, CYP2E1 | PRSS1 894/4885PRSS2 734/4885PRSS3 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.