Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29253153 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28987654 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27829175 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7262312 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10794900 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27858291 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1519074 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28425653 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28117275 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28220018 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15647 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4748924-A2 | PERFUSION CULTURE METHOD | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2026-05-27 | — | — | EP | claimed |
| CN-121160469-B | Symbiotic system of single-star algae and chaetomium globosum as well as construction method and application thereof | SHANDONG PENGBO BIOTECHNOLOGY Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-121757996-B | Scale inhibition and sterilization water treatment material and preparation method thereof | Shaanxi Longyu International Technology Group Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122091594-A | Microporous copper foil current collector for in-situ growth of carbon nanotubes and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074040-A | Device and method for sensitive biological sample storage | 安必恩生物科学公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260139154-A1 | CMP SLURRY COMPOSITION FOR POLISHING PATTERNED TUNGSTEN WAFER AND METHOD OF POLISHING PATTERNED TUNGSTEN WAFER USING THE SAME | SAMSUNG SDI CO., LTD. (KR) | 2026-05-21 | — | — | US | claimed |
| CN-122070009-A | CMP slurry composition for polishing patterned tungsten wafer and method for polishing patterned tungsten wafer using the same | 三星SDI株式会社 | 2026-05-19 | — | — | CN | claimed |
| CN-117920358-B | Liquid-phase high-sulfur-capacity catalyst and preparation, application and regeneration method thereof | 中国石油化工股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122033010-A | Pesticide polluted soil combined restoration structure and method based on microorganisms | 苏州金螳螂园林绿化景观有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122031516-A | Application of ferric ammonium citrate in preparation of medicine for resisting grouper iridovirus | 华南农业大学 | 2026-05-15 | — | — | CN | claimed |
| EP-0051038-A1 | Green colored polyester | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1982-05-05 | — | — | EP | claimed |
| US-4294726-A | Catalyst for the purification of exhaust gases of internal combustion engines | DEUTSCHE GOLD-UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1981-10-13 | — | — | US | claimed |
| US-4250250-A | Photographic process | MITA INDUSTRIAL COMPANY LIMITED (JP) | 1981-02-10 | — | — | US | claimed |
| US-4173453-A | Topical hair coloring formulation in the form of suspension, lotion and cream | CDC Research Inc. (US) | 1979-11-06 | — | — | US | claimed |
| US-4173515-A | FERRIC AMMONIUM CITRATE, ESCULIN HYDROLYSATE, ANTIBIOTIC INHIBITOR | MCDONNELL DOUGLAS CORPORATION (US) | 1979-11-06 | — | — | US | claimed |
| US-4171379-A | ELEMENTAL IRON, MAGNESIUM OXIDE, FATS, CLAYS, AND A PHOSPHORUS SOURCE | RALSTON PURINA COMPANY (US) | 1979-10-16 | — | — | US | claimed |
| US-4152211-A | Iron containing cell mass glucose isomerase preparation | NOVO INDUSTRI A/S (DK) | 1979-05-01 | — | — | US | claimed |
| US-4142991-A | TITANIUM TRICHLORIDE | STAUFFER CHEMICAL COMPANY (US) | 1979-03-06 | — | — | US | claimed |
| US-4049494-A | Vaccine production process | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1977-09-20 | — | — | US | claimed |
| US-3951894-A | CHLORINE OR BROMINE ORGANIC FIRERETARDANT, ACRYLONITRILE-BUTADIENE-STYRENE POLYMER | UNIROYAL INC. (US) | 1976-04-20 | — | — | US | claimed |