Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | RGS12 | O14924 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7640121 | 0.94 | ITGB3 (0.46) | ITGB3ITGA2BBACE1SIGMAR1LMNA | |
| SCHEMBL6600817 | 0.93 | ITGB3 (0.59) | ITGB3ITGA2BBACE1PRSS1PRSS2 | |
| SCHEMBL7633405 | 0.93 | ITGB3 (0.44) | ITGB3ITGA2BBACE1PRSS1PRSS2 | |
| SCHEMBL7639414 | 0.93 | ITGB3 (0.44) | ITGB3ITGA2BBACE1PRSS1PRSS2 | |
| SCHEMBL7638248 | 0.92 | ITGB3 (0.42) | ITGB3ITGA2BBACE1PRSS1PRSS2 | |
| SCHEMBL7637110 | 0.91 | ITGB3 (0.42) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7637336 | 0.90 | ITGB3 (0.43) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7634270 | 0.90 | ITGB3 (0.48) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7634011 | 0.90 | ITGB3 (0.53) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601532 | 0.88 | GRM2 (0.40) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |