Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 3/20 | 0.38 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | F11 | P03951 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NPR3 | P17342 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 2/20 | 0.34 |
| ▸ | XPNPEP2 | O43895 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27556964 | 1.00 | PEPD (0.38) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL7642022 | 0.87 | PEPD (0.39) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL27554019 | 0.87 | PEPD (0.39) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL7646534 | 0.87 | PEPD (0.39) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL28746793 | 0.83 | CNR2 (0.45) | PEPDXPNPEP1ACEPOLBCNR2 | |
| SCHEMBL7644398 | 0.83 | CNR2 (0.45) | PEPDXPNPEP1ACEPOLBCNR2 | |
| SCHEMBL7546728 | 0.81 | ACE (0.38) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL27569196 | 0.81 | ACE (0.38) | PEPDXPNPEP1DPP4F2F11 | |
| SCHEMBL7598645 | 0.79 | ALDH1A1 (0.46) | TSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7404249 | 0.79 | ACE (0.42) | PEPDF2ACEXPNPEP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468977-B1 | COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS | APOTEX INC. (CA) | 2002-10-22 | — | — | US | disclosed |
| CN-1291993-A | Thiadiazole compounds useful as cysteine activity dependent enzyme inhibitors | APOTEX INC (CA) | 2001-04-18 | — | — | CN | disclosed |
| US-6162791-A | Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes | APOTEX INC. (CA) | 2000-12-19 | — | — | US | disclosed |