Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 11/20 | 0.36 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7640471 | 1.00 | KDM4E (0.36) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL9565792 | 0.75 | SOAT1 (0.63) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL3378259 | 0.75 | SOAT1 (0.63) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL29972770 | 0.75 | SOAT1 (0.63) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL9525341 | 0.72 | SOAT1 (0.47) | SOAT1ACAT1 | |
| SCHEMBL9597124 | 0.71 | SOAT1 (0.48) | SOAT1ACAT1 | |
| SCHEMBL9214981 | 0.71 | SOAT1 (0.33) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL9214975 | 0.71 | SOAT1 (0.33) | KDM4EHPGDSMN1; SMN2SOAT1ACAT1 | |
| SCHEMBL11410845 | 0.63 | ESR1 (0.45) | KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10963408 | 0.62 | KDM4E (0.40) | KDM4EHPGDSMN1; SMN2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229907-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001034127-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |