Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645866 | 1.00 | KMT2A (0.45) | KMT2ACA12CA1CA2NLN | |
| SCHEMBL7643594 | 1.00 | KMT2A (0.45) | KMT2ACA12CA1CA2NLN | |
| Bromide SCHEMBL9551371 | 0.99 | KMT2A (0.44) | KMT2ACA12CA1CA2NLN | |
| SCHEMBL7618103 | 0.91 | LTA4H (0.48) | — | |
| SCHEMBL7618099 | 0.91 | LTA4H (0.48) | — | |
| SCHEMBL23573011 | 0.90 | NLN (0.47) | NLN | |
| SCHEMBL13073718 | 0.90 | NLN (0.47) | NLN | |
| SCHEMBL21794913 | 0.90 | NLN (0.47) | NLN | |
| SCHEMBL7622435 | 0.89 | CTSC (0.42) | — | |
| SCHEMBL3217867 | 0.89 | CTSC (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448282-B1 | H3 HISTAMINE RECEPTOR ANTAGONIST ACTIVITY; ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE, DEPRESSION, SCHIZOPHRENIA, NARCOLEPSY, SLEEP APNEA, INSOMNIA, EPILEPSY, HYPOTHALAMIC DYSFUNCTION | GLIATECH, INC. | 2002-09-10 | — | — | US | disclosed |
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | disclosed |