Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 8/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764383 | 0.85 | NPC1 (0.34) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL763256 | 0.85 | NPC1 (0.34) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL761654 | 0.81 | RAB9A (0.43) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL17558083 | 0.81 | RAB9A (0.43) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL19997586 | 0.81 | RAB9A (0.43) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL19997585 | 0.81 | RAB9A (0.43) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL761670 | 0.81 | RAB9A (0.43) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL19632888 | 0.79 | TSHR (0.42) | RAB9ANPC1TSHRHDAC4STING1 | |
| SCHEMBL17558067 | 0.73 | TSHR (0.42) | RAB9ANPC1TSHRPTGS2HTT | |
| SCHEMBL1755657 | 0.72 | RAB9A (0.40) | RAB9ANPC1TSHRHDAC4STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138353-B2 | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors | GENZYME CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |