Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645521 | 1.00 | KMT2A (0.43) | KMT2AMEN1EPHX1POLBRECQL | |
| SCHEMBL7645517 | 1.00 | KMT2A (0.43) | KMT2AMEN1EPHX1POLBRECQL | |
| SCHEMBL7544156 | 0.89 | KMT2A (0.42) | KMT2AMEN1POLBALDH1A1NPSR1 | |
| SCHEMBL7639660 | 0.89 | KMT2A (0.42) | KMT2AMEN1POLBALDH1A1NPSR1 | |
| SCHEMBL7642333 | 0.89 | KMT2A (0.42) | KMT2AMEN1POLBALDH1A1NPSR1 | |
| SCHEMBL7639665 | 0.89 | KMT2A (0.42) | KMT2AMEN1POLBALDH1A1NPSR1 | |
| SCHEMBL7550028 | 0.88 | KMT2A (0.46) | KMT2AMEN1EPHX1POLBRECQL | |
| SCHEMBL7543076 | 0.88 | KMT2A (0.46) | KMT2AMEN1EPHX1POLBRECQL | |
| SCHEMBL7543080 | 0.88 | KMT2A (0.46) | KMT2AMEN1EPHX1POLBRECQL | |
| SCHEMBL7541940 | 0.88 | KMT2A (0.46) | KMT2AMEN1EPHX1POLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | claimed |
| US-6462046-B2 | NON-THIAZOLIDINEDIONE PPARGAMMA AGONISTS; USEFUL IN MODULATION OF BLOOD GLUCOSE AND THE INCREASE OF INSULIN SENSITIVITY IN MAMMALS | ADVANCED SYNTECH, LLC | 2002-10-08 | — | — | US | disclosed |