Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686177 | 0.88 | ADORA1 (0.68) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL4985610 | 0.84 | ADORA1 (0.65) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL5500282 | 0.82 | ADORA1 (0.62) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL7439146 | 0.82 | ADORA1 (0.70) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL7431499 | 0.82 | ADORA1 (0.70) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL8005373 | 0.81 | ADORA1 (0.76) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL4621677 | 0.79 | ADORA1 (1.00) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL6843495 | 0.79 | ADORA1 (0.65) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL4982428 | 0.79 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BADORA3MEN1 | |
| SCHEMBL3691346 | 0.78 | ADORA1 (0.64) | ADORA1ADORA2AADORA2BADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230241-A2 | ADENOSINE RECEPTOR ANTAGONISTS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001034604-A2 | ADENOSINE RECEPTOR ANTAGONISTS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2001-05-17 | — | — | WO | disclosed |